Sheryl is beautiful, strong and self-assured, and she carries her confidence through her music. Sheryl was originally from the Macross Galaxy fleet where she was raised by her foster parent Grace O'Connor. She helps recognize the singing talent of Ranka Lee. As the series progresses, the two share a friendly professional and romantic rivalry. The object of their affection is pilot Alto Saotome.
Born to Abel and Sally Nome, Sheryl's family was among the many who rebelled against the mandatory cybernetic implants of the Macross galaxy, escaping from her home when the government came for the dissidents. She was able given the Fold Quartz earrings as the sole link to her family
Sheryl was found living on the streets of the the Macross Galaxy fleet. She was found by Grace O'Connor, who recruited her into Erato Academy, an academy known for children who had been disowned but found it difficult to exceed due to the trauma of her family's death.
The Fold Quartz earrings activated during a musical to see who would obtain the main role. Around that time she befriended Lilyth Amagi, the daughter of a Kabuki Actor family who was competing with the Saotome. The Fold Quartz earrings would activate by her singing. Lylith sacrificed herself to save Sheryl and also raises Grace's interest in Sheryl. Thanks to her newfound resolve, Sheryl becomes a better singer and became a vital part of Grace's personal agenda.
Unbeknownst to her, her grandmother was Mao Nome who died many years ago following a Vajra attack. She inherited a special set of Fold Quartz earrings, which she later discovers holds a secret power that is affected by her music.
Vajra ConflictEditMacross Frontier space colony as part of her tour. She encountered Alto Saotome who was a backup performer for her concert. After an attack by an alien species on the colony, her fans tried to escape thedevastating attack while she drove off safely with Grace and Catherine in a limousine, aggravating Alto due to the fact that Sheryl bore no thought in her heart for her many fans. (F: "Cross Encounter")
- In the February 2016 issue of NewType Magainze, Sheryl Nome was ranked the tenth best female character.
- In the July 2016 issue of NewType Magazine, Sheryl Nome was ranked the eighth best female character.
- In Macross 30: The Voice that Connects the Galaxy, she serves as the narrator of Macross History in the game's gallery mode and given the title of "Professor".